A case‐control study of Parkinson's disease in a horticultural region of British Columbia
Identifieur interne : 004284 ( Main/Exploration ); précédent : 004283; suivant : 004285A case‐control study of Parkinson's disease in a horticultural region of British Columbia
Auteurs : Clyde Hertzman ; Michele Wiens [Canada] ; Barry Snow ; Shona Kelly ; Donald CalneSource :
- Movement Disorders [ 0885-3185 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Agricultural Workers' Diseases (chemically induced), Agricultural Workers' Diseases (diagnosis), Agricultural workers, British Columbia, Case-Control Studies, Environmental exposure, Epidemiology, Female, Human, Humans, Male, Middle Aged, Occupational Exposure (adverse effects), Occupational exposure, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (diagnosis), Parkinson disease, Parkinson's disease, Pesticides, Pesticides (adverse effects), Risk Factors, Toxins.
- MESH :
- chemical , adverse effects : Pesticides.
- geographic : British Columbia.
- adverse effects : Occupational Exposure.
- chemically induced : Agricultural Workers' Diseases, Parkinson Disease, Secondary.
- diagnosis : Agricultural Workers' Diseases, Parkinson Disease, Secondary.
- Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
We compared personal histories of 127 cases and 245 controls to identify possible environmental risk factors for idiopathic parkinsonism (IP). Of our controls, 121 had cardiac disease (CD) and 124 were randomly selected from electoral lists (voters). Using logistic regression and adjusting for sex and age, we ran separate analyses: IP versus CD and IP versus voters. A full occupational history was collected, as was known contact with all pesticides associated with the tree fruit sector of the agricultural industry. We found a significant association between IP and having had an occupation in which exposure through handling or directly contacting pesticides was probable, but no specific chemicals were associated with IP. We conclude that although occupations involving the use of agricultural chemicals may predispose to the development of IP, it seems likely that the pathogenesis is multifactorial rather than related to a specific agent.
Url:
DOI: 10.1002/mds.870090111
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="69">69</biblScope><biblScope unit="page" to="75">75</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9390274BEFED7A2C1B5EABCBA05F1D129D06BBA4</idno><idno type="DOI">10.1002/mds.870090111</idno><idno type="ArticleID">MDS870090111</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Agricultural Workers' Diseases (chemically induced)</term><term>Agricultural Workers' Diseases (diagnosis)</term><term>Agricultural workers</term><term>British Columbia</term><term>Case-Control Studies</term><term>Environmental exposure</term><term>Epidemiology</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Occupational Exposure (adverse effects)</term><term>Occupational exposure</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (diagnosis)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pesticides</term><term>Pesticides (adverse effects)</term><term>Risk Factors</term><term>Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>British Columbia</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Colombie britannique</term><term>Epidémiologie</term><term>Exposition professionnelle</term><term>Homme</term><term>Parkinson maladie</term><term>Pesticide</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Pesticide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared personal histories of 127 cases and 245 controls to identify possible environmental risk factors for idiopathic parkinsonism (IP). Of our controls, 121 had cardiac disease (CD) and 124 were randomly selected from electoral lists (voters). Using logistic regression and adjusting for sex and age, we ran separate analyses: IP versus CD and IP versus voters. A full occupational history was collected, as was known contact with all pesticides associated with the tree fruit sector of the agricultural industry. We found a significant association between IP and having had an occupation in which exposure through handling or directly contacting pesticides was probable, but no specific chemicals were associated with IP. We conclude that although occupations involving the use of agricultural chemicals may predispose to the development of IP, it seems likely that the pathogenesis is multifactorial rather than related to a specific agent.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Calne, Donald" sort="Calne, Donald" uniqKey="Calne D" first="Donald" last="Calne">Donald Calne</name><name sortKey="Hertzman, Clyde" sort="Hertzman, Clyde" uniqKey="Hertzman C" first="Clyde" last="Hertzman">Clyde Hertzman</name><name sortKey="Kelly, Shona" sort="Kelly, Shona" uniqKey="Kelly S" first="Shona" last="Kelly">Shona Kelly</name><name sortKey="Snow, Barry" sort="Snow, Barry" uniqKey="Snow B" first="Barry" last="Snow">Barry Snow</name></noCountry><country name="Canada"><noRegion><name sortKey="Wiens, Michele" sort="Wiens, Michele" uniqKey="Wiens M" first="Michele" last="Wiens">Michele Wiens</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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